Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.4K
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

9
Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
9
Colonisation of Pathogens01:25

Colonisation of Pathogens

12
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
12
DNA Bacteriophages01:26

DNA Bacteriophages

1.3K
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
1.3K
Bacterial Phylum Proteobacteria01:26

Bacterial Phylum Proteobacteria

1.1K
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
1.1K
Cytoskeletal Proteins in Bacteria01:29

Cytoskeletal Proteins in Bacteria

4.4K
Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adapted Live SARS-CoV-2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5.

European journal of immunology·2026
Same author

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis.

bioRxiv : the preprint server for biology·2026
Same author

Modeling immune responses of cattle to <i>Mycobacterium bovis</i> using magnetic bioprinted granulomas.

mSphere·2025
Same author

A dual nature of γδ T cell immune memory responses.

eLife·2025
Same author

Bat organoids reveal antiviral responses at epithelial surfaces.

Nature immunology·2025
Same author

Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells.

Viruses·2025

Related Experiment Video

Updated: Mar 24, 2026

Study of Phagolysosome Biogenesis in Live Macrophages
08:06

Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 10, 2014

14.9K

Molecular Determinants in Phagocyte-Bacteria Interactions.

Stefan H E Kaufmann1, Anca Dorhoi1

  • 1Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

Immunity
|March 17, 2016
PubMed
Summary

Phagocytes, including neutrophils and mononuclear cells, are vital for fighting bacterial infections by engulfing and destroying pathogens. This review updates mechanisms of phagocyte functions against diverse bacterial invaders.

More Related Videos

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

1.0K
Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages
10:33

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Published on: October 25, 2017

11.3K

Related Experiment Videos

Last Updated: Mar 24, 2026

Study of Phagolysosome Biogenesis in Live Macrophages
08:06

Study of Phagolysosome Biogenesis in Live Macrophages

Published on: March 10, 2014

14.9K
Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

1.0K
Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages
10:33

Isolation of Salmonella typhimurium-containing Phagosomes from Macrophages

Published on: October 25, 2017

11.3K

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Phagocytes are essential for host defense against bacterial pathogens.
  • Neutrophils and mononuclear phagocytes exhibit distinct roles in combating extracellular and intracellular bacteria, respectively.
  • Pathogens have evolved mechanisms to evade phagocytosis and intracellular killing.

Purpose of the Study:

  • To provide an updated overview of the molecular and cellular mechanisms of phagocyte functions in antibacterial defense.
  • To highlight the plasticity and versatility of phagocyte phenotypes.
  • To examine phagocyte interactions with other cells in orchestrating host responses.

Main Methods:

  • Review of molecular and cellular mechanisms.
  • Focus on four exemplary bacterial pathogens with varying lifestyles (extracellular to intracellular).

Main Results:

  • Phagocytes demonstrate plasticity in adapting to different pathogen types.
  • Pathogens employ strategies to subvert phagocyte functions.
  • Phagocytes engage in complex crosstalk with host cells to modulate immune responses.

Conclusions:

  • Understanding phagocyte dynamics is crucial for developing effective antibacterial strategies.
  • Phagocyte plasticity and intercellular communication are key to managing diverse bacterial infections.
  • This review offers insights into host-pathogen interactions at the molecular and cellular levels.