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A Pioneer's Tail
1Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA.
Immunity
|March 17, 2016
Abstract:
In this issue of Immunity, Boller et al. (2016) show that a C-terminal domain of EBF1 is required for chromatin binding and induction of DNase I hypersensitive sites. These properties mark EBF1 as a pioneer factor in B cell development and demonstrate a role for non-DNA binding domains in this process.
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