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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Related Experiment Video

Updated: Mar 24, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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Endothelial Cell-Immune Cell Interaction in IBD.

Silvio Danese1, Claudio Fiocchi

  • 1IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Milan, Italy.

Digestive Diseases (Basel, Switzerland)
|March 17, 2016
PubMed
Summary

Immune cell trafficking to the gut is vital for health, with disruptions linked to diseases like inflammatory bowel disease. Understanding leukocyte-endothelial cell interactions offers therapeutic targets.

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Leukocyte (immune cell) delivery to tissues is crucial for health.
  • Abnormal leukocyte distribution is associated with various diseases.
  • The gut harbors abundant immunocytes and receives constant leukocyte influx, regulated by complex factors.

Purpose of the Study:

  • To elucidate the intricate mechanisms governing leukocyte trafficking in the gut.
  • To identify how dysregulation of these mechanisms contributes to inflammatory conditions.
  • To explore therapeutic opportunities by targeting leukocyte-endothelial cell interactions.

Main Methods:

  • Analysis of cell adhesion molecules and their counter-receptors on endothelial cells.
  • Investigation of chemokine and cytokine signaling pathways.

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  • Examination of factors influencing leukocyte exit and circulation.

    • Main Results:

    • Identified multiple regulatory factors controlling leukocyte influx into the gut.
    • Highlighted the role of cell adhesion molecules and chemokines in immune cell homing.
    • Demonstrated that disruptions in these regulatory mechanisms can precipitate inflammation.

    Conclusions:

    • Leukocyte-endothelial cell crosstalk is essential for maintaining gut homeostasis.
    • Dysfunctional interactions between these cells are implicated in inflammatory bowel disease.
    • Targeting these cellular communications presents a promising therapeutic strategy.