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Related Experiment Video

Updated: Mar 24, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: new comorbidities.

Jackson Machado-Pinto1, Michelle dos Santos Diniz1, Nádia Couto Bavoso1

  • 1Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.

Anais Brasileiros De Dermatologia
|March 17, 2016
PubMed
Summary

Psoriasis is a multisystem inflammatory disease linked to numerous comorbidities. This review explores new associations, including osteoporosis, obstructive sleep apnea, and chronic obstructive pulmonary disease, highlighting the need for further research.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pulmonology
  • Endocrinology

Background:

  • Psoriasis, once viewed as a skin-only condition, is now recognized as a systemic inflammatory disease.
  • A significant majority of psoriasis patients (73%) experience at least one comorbidity.
  • Established comorbidities include inflammatory bowel disease, uveitis, psychiatric disorders, metabolic syndrome, and cardiovascular diseases.

Purpose of the Study:

  • To review current literature on emerging comorbidities associated with psoriasis.
  • To examine the potential links between psoriasis and osteoporosis, obstructive sleep apnea (OSA), and chronic obstructive pulmonary disease (COPD).

Main Methods:

  • Systematic review of existing scientific literature.

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  • Analysis of studies investigating associations between psoriasis and osteoporosis, OSA, and COPD.
  • Identification of common risk factors and potential confounders.

    • Main Results:

    • Evidence suggests a possible association between psoriasis and osteoporosis, particularly in males.
    • Psoriasis and COPD share common risk factors like obesity, smoking, and physical inactivity, potentially confounding their association.
    • Current data indicate a potential link between psoriasis and OSA, but studies are limited by small sample sizes and short follow-up.

    Conclusions:

    • Further prospective studies are needed to establish causality between psoriasis and these newly identified comorbidities, controlling for confounding factors.
    • The systemic inflammatory nature of psoriasis likely underlies its association with various multisystemic conditions.