Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Approach to the dementia research].

M Tomonaga

    Rinsho Shinkeigaku = Clinical Neurology
    |December 1, 1989
    PubMed
    Summary

    Dementia in the elderly, primarily Alzheimer's and vascular types, involves complex protein changes and neuronal damage. Research highlights key proteins like amyloid and tau, and neurotransmitter deficits, offering insights into disease mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303.

    British journal of haematology·2001
    Same author

    Morphological diagnoses of the Japan adult leukemia study group acute myeloid leukemia protocols: central review.

    International journal of hematology·2001
    Same author

    Effect of a selective Abl tyrosine kinase inhibitor, STI571, on in vitro growth of BCR-ABL-positive acute lymphoblastic leukemia cells.

    Leukemia·2001
    Same author

    Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki.

    Blood·2001
    Same author

    Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

    Cancer research·2001
    Same author

    Expression of survivin in HTLV-I-infected T-cell lines and primary ATL cells.

    Biochemical and biophysical research communications·2001

    Area of Science:

    • Neurology
    • Neuroscience
    • Pathology

    Context:

    • Dementia in the elderly is a growing concern, with vascular dementia and Alzheimer's dementia being the primary causes.
    • Increasing incidence of diffuse vascular leukoencephalopathy and amyloid angiopathy are noted.
    • Understanding the molecular and structural changes in the brain is crucial for dementia research.

    Purpose:

    • To explore the underlying protein chemistry and cellular changes in Alzheimer's dementia.
    • To investigate the role of specific proteins like amyloid precursor protein (APP) and tau protein in neurodegeneration.
    • To examine neurotransmitter deficits and potential new pathogenic mechanisms in dementia.

    Summary:

    • Alzheimer's dementia involves amyloid (beta protein, A4 protein) derived from APP on chromosome 21, and tau protein forming neurofibrillary tangles.
    • Beta protein is present in normal aged brains, while abnormal tau neurite sprouting is linked to dementia and neural death.
    • Reduced neurotransmitters like acetylcholine and structural brain changes are characteristic of Alzheimer's dementia.
    • Olfactory bulb and mucosal changes are emerging as potential pathogenic factors.
    • Delayed neuronal death, a phenomenon of vascular origin, warrants further study in vascular dementia.

    Impact:

    • Provides a deeper understanding of the molecular pathology of Alzheimer's and vascular dementia.
    • Identifies key proteins and cellular processes involved in neurodegeneration.
    • Suggests new avenues for diagnostic and therapeutic strategies for dementia.
    • Highlights the importance of studying delayed neuronal death in vascular dementia.

    Related Experiment Videos