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Related Concept Videos

Cytoplasm01:16

Cytoplasm

94.6K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
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Related Experiment Video

Updated: Mar 24, 2026

Expression and Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein in Saccharomyces cerevisiae
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[Is the time ripe for cytosorb].

Markus Gehling, Michael Tryba

    Deutsche Medizinische Wochenschrift (1946)
    |March 17, 2016
    PubMed
    Summary

    Cytokine hemofiltration using Cytosorb may reduce sepsis-related cytokines. However, clinical data is needed to prove its efficacy in improving survival rates for septic shock patients.

    Area of Science:

    • Critical care medicine
    • Immunology
    • Biomedical engineering

    Context:

    • Sepsis is a life-threatening condition characterized by a dysregulated host response to infection.
    • Cytokines play a crucial role in the pathogenesis of sepsis and septic shock, particularly in the development of vasodilatory shock.
    • Cytosorb, a hemofiltration device, is CE-approved for cytokine removal in sepsis.

    Purpose:

    • To evaluate the potential clinical efficacy of Cytosorb hemofiltration in reducing cytokines during sepsis.
    • To discuss the limitations and the need for clinical data regarding Cytosorb's impact on sepsis mortality.
    • To critically assess the benefits and risks of non-specific cytokine elimination in sepsis.

    Summary:

    • Hemofiltration with Cytosorb aims to reduce cytokine levels in sepsis patients.

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  • Cytokine reduction may potentially improve survival in septic shock, but clinical evidence is currently lacking.
  • Non-specific elimination of both pro- and anti-inflammatory cytokines presents complex clinical effects and requires further investigation.

    • Impact:

    • Highlights the urgent need for robust clinical trials to validate the efficacy of Cytosorb in sepsis treatment.
    • Emphasizes the importance of understanding cytokine interactions to determine the true clinical value of cytokine elimination therapies.
    • Informs critical discussion on the limitations of current sepsis treatment strategies and the potential role of extracorporeal cytokine removal.