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[Effect of Different Processed Products and Extracts of Morinda officinalis Root on Adjuvant-Induced Arthritis in
Objective:
To study the therapeutic effects of different processed products and extracts of Morinda officinalis root in rat adjuvant-induced arthritis (AA) model, and to explore the possible mechanism.
Methods:
AA model in SD rats was established, then the arthritic rats were randomly divided into seven groups such as model, Tripterygium Glycosides Tablet (TGT), morinda with xylem, morinda, salt-steamed morinda, licorice-processed morinda, morinda EtOAc extract, morinda n-BuOH extract, H₂O residue, total polysaccharides and control groups. The paw edema and arthritis indexes were observed, and the contents of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-2 and INF-γ in AA rats serum were detected by ELISA.
Results:
Morinda processed by salt and n-BuOH extract could reduce paw swelling and levels of TNF-α, IL-1β, IL-6 and INF-γ in AA rats serum, which followed by morinda EtOAc extract. The differences were significant compared with the model group (P < 0.05 or P < 0.01).
Conclusion:
Salt-steamed morinda and morinda n-BuOH extract have the best curative effect, followed by morinda EtOAc extract. Reducing TNF-α, IL-1β, IL-6 and INF-γ contents in serum may be the mechanism of drug treatment of rheumatoid arthritis.
