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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Enhancing evidence informed policymaking in complex health systems: lessons from multi-site collaborative approaches
Etienne V Langlois1, Victor Becerril Montekio2, Taryn Young3,4
1Alliance for Health Policy and Systems Research, World Health Organization, 20 avenue Appia, 1211, Geneva, Switzerland. langloise@who.int.
Collaborative research and policy interventions improved evidence use in low-resource health systems. These approaches fostered better policymaking by connecting researchers with policymakers for sustained engagement.
Area of Science:
- Health Policy and Systems Research
- Implementation Science
- Global Health
Background:
- Growing global emphasis on evidence-informed health policymaking to enhance health system performance.
- Need for collaborative strategies to integrate research knowledge into real-world policy and practice.
- Implementation of multi-site, evidence-to-policy interventions in low-resource settings.
Purpose of the Study:
- To reflect on the implementation and impact of two distinct evidence-to-policy interventions.
- To assess the effectiveness of collaborative approaches in bridging the research-policy gap.
- To provide insights for developing and supporting future evidence-to-policy initiatives.
Main Methods:
- Intervention 1: Implementation research using communities of practice (CoP) in Mexico and Nicaragua for maternal health.
- Process evaluation of CoPs assessing stakeholder capacity to acquire, analyze, adapt, and apply research.
- Intervention 2: Policy BUilding Demand for evidence in Decision making through Interaction and Enhancing Skills (Policy BUDDIES) in South Africa and Cameroon, using a 'buddying' process for systematic review use.
- Realist evaluation of the Policy BUDDIES initiative.
Main Results:
- CoP-supported research in Mexico led to local health organizations monitoring maternal healthcare quality.
- Professionals in Mexico and Nicaragua reported enhanced capacity to identify and use evidence for implementation challenges.
- Policy BUDDIES in South Africa informed a policy framework for chronic disease medication adherence.
- Policymakers in Policy BUDDIES reported increased recognition of research value and demand for policy-relevant knowledge.
Conclusions:
- Collaborative evidence-to-policy approaches require iterative engagement and continuity between researchers and policymakers.
- Fit-for-purpose strategies are crucial, adapting processes and knowledge to different policymaking cycle needs.
- Approaches embedding research use in real-world policymaking are better suited to complex, adaptive health systems.
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