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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Ethno-Specific Risk Factors for Adverse Pregnancy Outcomes: Findings from the Born in Bradford Cohort Study
Tomasina Stacey1, Stephanie Prady2, Melanie Haith-Cooper3
1School of Healthcare, University of Leeds, Leeds, LS2 9JT, UK. t.stacey@leeds.ac.uk.
Insights
Financial strain significantly increases preterm birth (PTB) risk. Maternal distress in Pakistani women was linked to lower small for gestational age (SGA) rates, highlighting ethnic differences in perinatal risk factors.
Area of Science:
- Maternal and Child Health
- Perinatal Epidemiology
- Sociology of Health
Background:
- Preterm birth (PTB) and small for gestational age (SGA) are leading causes of perinatal mortality and morbidity.
- Maternal psychosocial and economic well-being are implicated as risk factors for adverse perinatal outcomes.
Purpose of the Study:
- To investigate the association between psycho-social and economic factors and perinatal outcomes in an ethnically diverse population.
- To identify ethno-specific risk factors for PTB and SGA.
Main Methods:
- Analysis of data from 9680 singleton live births in the Born in Bradford cohort study (2007-2010).
- Maternal socio-demographic and mental health data collected at baseline; outcome data collected prospectively.
- Multivariate regression models used to analyze PTB (<37 weeks' gestation) and SGA (<10th customized centile).
Main Results:
- Financial strain was associated with a 45% increased risk of PTB (OR 1.45).
- Maternal distress showed a negative association with SGA in Pakistani women (OR 0.65).
- Obesity was protective against PTB in White British women (OR 0.67); smoking and hypertension confirmed as risk factors.
Conclusions:
- Financial strain emerges as a significant risk factor for PTB.
- Significant ethnic variations in risk factors for PTB and SGA were observed.
- Understanding ethno-specific risks is crucial for developing targeted preventative strategies to improve perinatal outcomes in disadvantaged populations.
Abstract:
Objectives Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. This paper will explore a range of psycho-social and economic factors in an ethnically diverse population. Methods The UK's Born in Bradford cohort study recruited pregnant women attending a routine antenatal appointment at 26-28 weeks' gestation at the Bradford Royal Infirmary (2007-2010). This analysis includes 9680 women with singleton live births who completed the baseline questionnaire. Data regarding maternal socio-demographic and mental health were recorded. Outcome data were collected prospectively, and analysed using multivariate regression models. The primary outcomes measured were: PTB (<37 weeks' gestation) and SGA (<10th customised centile). Results After adjustment for socio-demographic and medical factors, financial strain was associated with a 45 % increase in PTB (OR 1.45: 95 % CI 1.06-1.98). Contrary to expectation, maternal distress in Pakistani women was negatively associated with SGA (OR 0.65: CI 0.48-0.88). Obesity in White British women was protective for PTB (OR 0.67: CI 0.45-0.98). Previously recognized risk factors, such as smoking in pregnancy and hypertension, were confirmed. Conclusions This study confirms known risk factors for PTB and SGA, along with a new variable of interest, financial strain. It also reveals a difference in the risk factors between ethnicities. In order to develop appropriate targeted preventative strategies to improve perinatal outcome in disadvantaged groups, a greater understanding of ethno-specific risk factors is required.
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