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Cognitive and Behavioral Outcomes of Intrauterine Growth Restriction School-Age Children

Juncao Chen1, Pingyang Chen2, Tao Bo1

  • 1Neonatal Division, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Pediatrics
|March 18, 2016
PubMed

Insights

Children with intrauterine growth restriction (IUGR) show lower cognitive scores in school age. More research is needed to understand IUGR

Area of Science:

  • Neurology
  • Developmental Pediatrics
  • Cognitive Science

Background:

  • Intrauterine growth restriction (IUGR) may lead to long-term neurological issues in children.
  • School-aged children with IUGR history face increased risks for developmental problems.

Purpose of the Study:

  • To evaluate the impact of IUGR on cognitive abilities and behavior in school-aged children.
  • To synthesize existing research on IUGR and neurodevelopmental outcomes.

Main Methods:

  • Systematic literature search of Medline, Embase, and PsycINFO for studies post-1980.
  • Inclusion of case-control studies assessing cognitive and behavioral data in children over five years old with IUGR.
  • Extraction of cognitive and behavioral data from 15 cognitive and 6 behavioral studies, totaling 1559 cases and 1630 controls.

Main Results:

  • Children with IUGR exhibited significantly lower cognitive scores compared to controls (SMD -0.38, P < .00001).
  • Cognitive scores in the IUGR group did not correlate significantly with birth weight or gestational age.
  • Behavioral scores differed significantly between IUGR and control groups (SMD 0.31, P = .001), though ADHD incidence was not significantly different.

Conclusions:

  • IUGR is linked to diminished cognitive performance in school-aged children.
  • The current body of research on IUGR's effects on behavioral disorders and ADHD is limited.
  • Larger, comprehensive studies are necessary to fully ascertain IUGR's impact on behavioral outcomes and ADHD.
Abstract

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