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Published on: July 19, 2024
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[Nonalcoholic fatty liver disease in the elderly]
1Department of Elderly Gastroenterology, The First Affiliated Hospital of China Medical University, Shengyang 110001, China.
Summary
As people age, nonalcoholic fatty liver disease (NAFLD) impairs liver function and increases risks for other serious conditions. This review offers insights into managing NAFLD in older adults, considering their unique health challenges.
Area of Science:
- Gerontology
- Hepatology
- Internal Medicine
Background:
- Aging significantly alters liver disease presentation and progression.
- Nonalcoholic fatty liver disease (NAFLD) in the elderly is linked to diminished liver function and increased risks of cardiovascular disease and cancer.
- Elderly individuals often present with frailty, malnutrition, limited mobility, comorbidities, and polypharmacy, complicating NAFLD management.
Purpose of the Study:
- To review the liver's structural and functional changes with aging.
- To discuss the specific challenges in diagnosing and treating NAFLD in the elderly.
- To propose evidence-based regimens for NAFLD management in older populations.
Main Methods:
- Comprehensive literature review focusing on aging and NAFLD.
- Analysis of morphological and functional liver changes in senescence.
- Synthesis of data on elderly-specific health factors impacting NAFLD.
- Evaluation of current diagnostic and therapeutic strategies.
Main Results:
- Aging affects liver structure and function, predisposing to NAFLD complications.
- Elderly patients with NAFLD face unique challenges due to comorbidities and polypharmacy.
- Current management guidelines may require adaptation for the geriatric population.
Conclusions:
- NAFLD poses a significant health burden in the elderly, impacting liver and overall health.
- Tailored diagnostic and treatment approaches are crucial for effective NAFLD management in older adults.
- This review provides a framework for clinical practice, emphasizing individualized care for elderly NAFLD patients.
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