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Various simultaneous nail changes due to valproic acid use.

Berna Solak1, Rabia Oztas Kara1, T Erdem1

  • 1a Department of Dermatology , School of Medicine, Sakarya University , Sakarya , Turkey.

Cutaneous and Ocular Toxicology
|March 18, 2016
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Summary
This summary is machine-generated.

Valproic acid, a widely used medication, can cause nail changes like discoloration and roughness. These nail abnormalities improved significantly after discontinuing the drug.

Keywords:
Antiepilepticdrugnailonycholysisvalproic acid

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Valproic acid is a commonly prescribed medication with a broad therapeutic index.
  • Nail changes associated with valproic acid are rarely reported in medical literature.

Observation:

  • A 50-year-old male patient presented with significant nail abnormalities.
  • Observed changes included onycholysis, nail surface roughness, and brownish-yellow discoloration of fingernails and toenails.

Findings:

  • The patient's nail conditions demonstrated remarkable improvement.
  • Cessation of valproic acid therapy led to the amelioration of the observed nail changes.

Implications:

  • This case highlights a potential, albeit uncommon, side effect of valproic acid.
  • Clinicians should consider valproic acid-induced nail changes in patients presenting with similar dermatological symptoms.
  • Further investigation into the mechanism of valproic acid's effect on nails may be warranted.