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Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection
Published on: June 16, 2020
In focus: Fe3O4 nanoparticles and human mesenteric artery interaction in vitro
Teodora I Vukova1, Stanislav D Dimitrov2, Hristo S Gagov3
1Department Excitable Structures, Institute of Biophysics & Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bldg. 21, 1113 Sofia, Bulgaria.
Aim:
The growing implementation of iron oxide nanoparticles in medicine requires a thorough investigation of their physiological influence. Therefore, effects of Fe3O4 nanoparticles on isometric contractions of healthy human mesenteric artery in vitro were investigated.
Materials & Methods:
The effect of increasing concentrations (0.023, 0.069, 0.23, 0.69 and 2.31 μg/μl) of Fe3O4 nanoparticles (50-100 nm) on the contractility of mesenteric artery ring preparations was studied using wire myography technique.
Results & Conclusion:
A lack of effects of Fe3O4 nanoparticles (50-100 nm) on isometric contractions of human mesenteric artery segments both in conditions of basal tension and precontraction was found. The observed unresponsiveness of human mesenteric arteries in vitro to Fe3O4 nanoparticles could be attributed to their safe mode of use in biomedicine.
