Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COP Coated Vesicles00:59

COP Coated Vesicles

18.6K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.6K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
3.3K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

9.8K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.8K
Exocytosis00:51

Exocytosis

75.0K
Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
75.0K
Exocytosis00:50

Exocytosis

10.0K
Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
10.0K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

5.2K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular cloning and heterologous expression of an acid-stable endoxylanase gene from Penicillium oxalicum in Trichoderma reesei.

Journal of microbiology and biotechnology·2013
Same author

Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers.

Experimental and therapeutic medicine·2013
Same author

Inhibitory effect of glutathione on oxidative liver injury induced by dengue virus serotype 2 infections in mice.

PloS one·2013
Same author

Efficacy of tribendimidine against Angiostrongylus cantonensis infection in the mice.

Parasitology research·2013
Same author

Double-bundle anatomical versus single-bundle isometric medial patellofemoral ligament reconstruction for patellar dislocation.

International orthopaedics·2013
Same author

Fatty acid binding proteins FABP9 and FABP10 participate in antibacterial responses in Chinese mitten crab, Eriocheir sinensis.

PloS one·2013

Related Experiment Video

Updated: Mar 24, 2026

Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

1.8K

Ciliary Extracellular Vesicles: Txt Msg Organelles.

Juan Wang1, Maureen M Barr2

  • 1Department of Genetics and The Human Genetics Institute of New Jersey, Rutgers University, 145 Bevier Road, Piscataway, NJ, 08854, USA.

Cellular and Molecular Neurobiology
|March 18, 2016
PubMed
Summary

Cilia, or sensory organelles, release extracellular vesicles (EVs) for intercellular communication. This study proposes cilia are dedicated organelles for EV biogenesis and reception, offering insights into ciliopathies.

Keywords:
C. elegansCiliaEctosomeExosomeExtracellular vesiclesMicrovesicle

More Related Videos

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

990
Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry
12:27

Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry

Published on: July 26, 2022

5.9K

Related Experiment Videos

Last Updated: Mar 24, 2026

Setting a Successful Sorting for Extracellular Vesicle Isolation
08:37

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

1.8K
Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

990
Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry
12:27

Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry

Published on: July 26, 2022

5.9K

Area of Science:

  • Cell Biology
  • Organelle Biology
  • Extracellular Vesicles

Background:

  • Cilia are sensory organelles on cell surfaces involved in environmental monitoring.
  • Cilia also release extracellular vesicles (EVs), a conserved intercellular communication method.
  • The relationship between cilia and EVs, and EV fundamental biology, remain largely unknown.

Purpose of the Study:

  • To propose the cilium as a dedicated organelle for EV biogenesis and reception.
  • To explore mechanisms of EV bioactivity.
  • To connect findings in model organisms to human ciliopathies.

Main Methods:

  • Review of existing literature on cilia and EVs.
  • Analysis of studies in model organisms (Chlamydomonas, C. elegans).
  • Discussion of proposed mechanisms for EV biogenesis, reception, and bioactivity.

Main Results:

  • EVs are shed from cilia tips and can be bioactive.
  • EV release from ciliated neurons is dependent on intraflagellar transport.
  • EV bioactivity is linked to cargo content and plays a role in animal communication.

Conclusions:

  • Cilia are proposed as dedicated organelles for EV biogenesis and reception.
  • Understanding ciliary EVs in model organisms can illuminate human ciliopathies.
  • Further research into cilia-EV interactions is crucial for advancing cell biology.