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Microvascular angina and panic disorder.

P P Roy-Byrne1, P Schmidt, R O Cannon

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle.

International Journal of Psychiatry in Medicine
|January 1, 1989
PubMed
Summary
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Patients with microvascular angina (MVA) and panic disorder (PD) share symptoms but differ psychologically. Some MVA patients exhibit PD traits, suggesting co-morbidity or distinct MVA origins.

Area of Science:

  • Cardiology
  • Psychiatry
  • Psychosomatic Medicine

Background:

  • Chest pain with normal coronary arteries is often diagnosed as microvascular angina (MVA).
  • Some patients with MVA also exhibit characteristics of panic disorder (PD).

Purpose of the Study:

  • To compare clinical and psychological features of MVA and PD patients.
  • To investigate the response to lactate infusion in MVA patients.

Main Methods:

  • Comparative analysis of 15 MVA patients and 15 PD patients.
  • Psychological assessments and clinical evaluations.
  • Lactate infusion challenge in a subset of MVA patients.

Main Results:

  • 40% of MVA patients met PD criteria and experienced chest pain post-lactate infusion.

Related Experiment Videos

  • Despite overlap, significant psychological and symptomatic differences were observed between MVA and PD groups.
  • Lactate infusion triggered chest pain in some MVA patients, consistent with PD responses.

    • Conclusions:

    • Findings suggest potential co-morbidity between MVA and PD.
    • Results may indicate two distinct MVA types: primary cardiac or a central phenomenon linked to PD-related autonomic arousal.