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A High Performance Pulsatile Pump for Aortic Flow Experiments in 3-Dimensional Models.

Rafeed A Chaudhury1, Victor Atlasman2, Girish Pathangey3

  • 1School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA. rafeed@asu.edu.

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Researchers developed a new piston-based pulsatile flow pump for cardiovascular research. This system accurately replicates aortic flow conditions for validating computational simulations of aortic diseases.

Keywords:
AortaBlood flowFlow loopHeart valvesPhysiological waveformPiston pumpPulsatile flow

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Fluid Dynamics

Background:

  • Aortic pathologies like aneurysms and dissections are critical cardiovascular diseases.
  • Computational simulations aid in understanding and surgical planning for these conditions.
  • In vitro experiments are essential for validating these simulations, requiring specialized pulsatile flow systems.

Purpose of the Study:

  • To design and validate a novel piston-based pulsatile flow pump system.
  • To meet the need for a system capable of replicating physiologic aortic flow conditions.
  • To provide a versatile and cost-effective solution for aortic flow experiments.

Main Methods:

  • A piston-based pulsatile flow pump system was designed and constructed.
  • The system's performance was evaluated using image processing of piston motion.
  • Particle image velocimetry (PIV) was employed to analyze flow dynamics.
  • Compatibility with high viscosity fluids and MRI environments was assessed.

Main Results:

  • The system achieved high volume flow rates (850 mL/s).
  • It successfully replicated physiologic waveforms and handled high impedances.
  • The pump demonstrated compatibility with various fluid types and MRI operation.
  • Validation confirmed accurate performance for aortic flow simulation.

Conclusions:

  • The newly designed pulsatile flow pump system offers enhanced capabilities for aortic flow research.
  • It provides a more effective solution compared to existing designs for in vitro validation.
  • The system is a cost-effective tool for advancing the understanding and treatment of aortic pathologies.