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Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Jian Liu1, Deodial Guiadeen1, Arto Krikorian1

  • 1Department of Early Development and Discovery Sciences, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.

ACS Medicinal Chemistry Letters
|March 18, 2016
PubMed

Keywords:
BTKX-ray crystal structurehuman peripheral blood mononuclear cells (hPBMC)kinase selectivitypharmacokineticrat CIA modelrheumatoid arthritis (RA)whole blood

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