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The Association of Mean Platelet Volume with Intra Ventricular Hemorrhage and Broncho Pulmonary Dysplasia in Preterm
K Bolouki Moghaddam1, M Zarkesh1, A Kamali1
1Pediatric growth disorders research center, 17 shahrivar hospital, school of medicine, Guilan University of medical sciences, Rasht, Iran.
Insights
Mean platelet volume (MPV) can predict interventricular hemorrhage (IVH) and bronchopulmonary dysplasia (BPD) in premature infants. Higher MPV levels in the first 48 hours indicate increased risk for these conditions.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Critical Care
Background:
- Interventricular hemorrhage (IVH) and bronchopulmonary dysplasia (BPD) are common in premature infants and linked to platelet dysfunction.
- Investigating the association between mean platelet volume (MPV) and the occurrence of IVH and BPD is crucial for early detection and management.
Purpose of the Study:
- To determine if mean platelet volume (MPV) can serve as a biomarker for the incidence of IVH and BPD in preterm neonates.
- To explore the correlation between MPV levels and the development of these serious neonatal conditions.
Main Methods:
- A cross-sectional study comparing three groups: IVH, BPD, and a control group of preterm neonates (<35 weeks gestation).
- MPV was measured within the first 48 hours of life.
- Statistical analysis included descriptive statistics, Pearson and Spearman correlation coefficients, paired t-tests, and multinomial regression analysis.
Main Results:
- Higher MPV levels were observed in both the BPD (9.79±0.73 fl) and IVH (10±1.04 fl) groups compared to the control group (8.33±0.91 fl) (p<0.0001).
- A significant majority of infants in the BPD (93.3%) and IVH (73.3%) groups had MPV >9 fl, versus only 16.7% in controls (p<0.0001).
- Regression analysis indicated MPV was significantly associated with IVH occurrence (OR=2.200, p=0.013) and predicted longer durations of oxygen therapy and mechanical ventilation.
Conclusions:
- MPV measured within the first 48 hours of life is a simple and effective biomarker for predicting the occurrence of BPD and especially IVH in preterm infants.
- Elevated MPV levels are strongly associated with increased risk and severity of IVH and BPD, highlighting its clinical utility in neonatal care.
Background:
Interventricular hemorrhage (IVH) and Broncho pulmonary dysplasia(BPD) commonly occur in premature infants and they associate with platelet dysfunction. The aim of this study was to investigate the association of MPV and occurrence of IVH and BPD.
Materials And Methods:
In this cross sectional study, 3 groups including IVH, BPD and control were compared. All participants were preterm neonates with <35 weeks of gestation. MPV was recorded during the first 48 hours of life for all cases. Data were reported by descriptive statistics and analyzed by Pearson correlation coefficient, spearman correlation coefficient, paired T test and multinomial regression analysis in SPSS version 17.
Results:
Higher MPV level was noted in BPD and IVH groups versus control group (9.79±0.73 fl and 10±1.04 fl versus 8.33±0,91 fl p<0.0001). Also, most participants in BPD (93.3%) and IVH (73.3%) groups had MPV >9 fl compared to controls (16.7%) (p<0.0001). Regression analysis showed that only MPV related to the occurrence of IVH (OR=2.200 95%CI p=0.013) and elevated MPV significantly increased duration of O2 therapy (p<0.0001) and mechanical ventilation (p=0.0010).
Conclusion:
MPV value at first 48 hours of life can be noted as a simple biomarker for occurrence of BPD and specially IVH in preterm infants.
