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Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease
Qing Li1, Yuan Zhang, Ding Ding
1Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Insights
High serum uric acid (SUA) levels increase mortality risk in Chinese coronary artery disease (CAD) patients. This association is stronger in those with better kidney function (eGFR ≥60).
Area of Science:
- Cardiology
- Nephrology
- Public Health
Background:
- Inconsistent findings exist regarding serum uric acid (SUA) and coronary artery disease (CAD) risks.
- Assessing SUA's independent impact on mortality in CAD patients is crucial.
Purpose of the Study:
- To evaluate the independent association between serum uric acid (SUA) and all-cause and cardiovascular disease (CVD) mortality in Chinese patients with CAD.
Main Methods:
- A prospective cohort study included 1,799 patients.
- Cox regression models were employed to analyze the association between SUA and mortality risk.
Main Results:
- Higher SUA quartiles correlated with significantly increased all-cause and CVD mortality.
- The association was more pronounced in patients with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2.
- No significant association was observed in patients with eGFR <60 ml/min/1.73 m2.
Conclusions:
- Elevated SUA levels are linked to higher all-cause and CVD mortality in CAD patients.
- Kidney function (eGFR) modifies the association between SUA and mortality risk.
Objectives:
Several studies have investigated the association between serum uric acid (SUA) and the risks of coronary artery disease (CAD) but have yielded inconsistent results. The aim of this study was to assess whether there is an independent association of SUA with all-cause and cardiovascular disease (CVD) mortality in Chinese patients with CAD.
Methods:
A prospective cohort study of 1,799 patients was conducted. Cox regression models were used to estimate the association of SUA with the risk of death.
Results:
During a median follow-up of 3.9 years, 177 deaths were recorded and 126 of these were due to CVD. Patients in the highest SUA quartile had a 2.43-fold risk of all-cause mortality and a 2.44-fold risk of CVD mortality compared with those in the lowest quartile. In the subpopulation analysis, the association between SUA and mortality remained similar when participants were stratified by age, gender, body mass index and type of CAD. In contrast, we found a significant interaction with estimated glomerular filtration rate (eGFR). There was a stronger association between SUA and the risk of all-cause and CVD mortality among patients with an eGFR ≥60 ml/min/1.73 m2, but no significant association was found in the population with an eGFR <60 ml/min/1.73 m2.
Conclusions:
Elevated SUA levels were positively associated with an increased risk of all-cause and CVD mortality among CAD patients.
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