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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas
Lenka Zlamalikova1, Mojmir Moulis1, David Salek2
1Department of Pathology, University Hospital, 625 00 Brno, Czech Republic.
Oncology Reports
|March 18, 2016
Summary
Cyclin D1 is a marker for mantle cell lymphoma (MCL). Overexpression of cyclin D2 in diffuse large B-cell lymphoma (DLBCL) indicates a poorer prognosis, impacting survival rates.
Area of Science:
- Molecular Biology
- Oncology
- Hematology
Background:
- D-type cyclins are crucial for cell cycle regulation and are implicated in lymphoma pathogenesis.
- Cyclin D1 overexpression is a hallmark of mantle cell lymphoma (MCL) and a diagnostic marker.
- Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group, necessitating stratification markers.
Purpose of the Study:
- To analyze the expression of cyclin D1, D2, and D3 mRNAs in MCL and DLBCL.
- To investigate the correlation between cyclin D expression and disease outcome in these lymphomas.
- To assess the potential of cyclin D expression for DLBCL stratification.
Main Methods:
- Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to analyze mRNA expression.
- Tumor tissues from 30 MCL patients and 104 DLBCL patients were analyzed.
- Statistical analysis was performed to determine the significance of cyclin D expression on survival.
Main Results:
- Cyclin D1 mRNA was highly expressed in 97% of MCL cases and absent in DLBCL.
- Cyclin D2 overexpression was observed in 10.6% of DLBCL cases, significantly more frequent than in MCL.
- High cyclin D2 expression in de novo DLBCL correlated with decreased overall and progression-free survival (P=0.016 and P=0.009, respectively).
- Cyclin D3 expression showed similar patterns in both lymphoma types and did not impact disease outcome.
Conclusions:
- Cyclin D1 serves as a reliable diagnostic marker for MCL.
- Cyclin D2 overexpression is a negative prognostic factor in DLBCL, suggesting its utility in risk stratification.
- Cyclin D3 expression is not associated with prognosis in MCL or DLBCL.
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