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Updated: Mar 24, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
Emerging nexus between RAB GTPases, autophagy and neurodegeneration
Navodita Jain1, Subramaniam Ganesh1
1a Department of Biological Sciences & Bioengineering , Indian Institute of Technology , Kanpur , India.
Abstract:
The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
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