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Sex-Related Differences Between Patients With Symptomatic Acute Aortic Dissection
Buamina Maitusong1, Hui-Ping Sun, Dilidaer Xielifu
1From the Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, People's Republic of China (BM, Y-TM, MM, H-PS, XM, XX, AA, X-RZ, DX); Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, People's Republic of China (Y-TM, FL).
Medicine
|March 18, 2016
Summary
Sex influences acute aortic dissection (AAD) presentation and outcomes. Women with AAD experience higher in-hospital mortality and more complications compared to men.
Area of Science:
- Cardiology
- Vascular Surgery
- Medical Research
Background:
- Acute aortic dissection (AAD) is a life-threatening condition.
- Understanding sex-related differences in AAD is crucial for tailored patient management and improved outcomes.
Purpose of the Study:
- To investigate sex-specific differences in the clinical manifestations, incidence, and outcomes of symptomatic acute aortic dissection (AAD).
Main Methods:
- Retrospective cohort study analyzing clinical data from 400 patients diagnosed with AAD between 2010 and 2015.
- Comparison of clinical characteristics, treatment, and outcomes between male and female patients.
Main Results:
- Women with AAD presented with higher age of onset and higher incidence of atherosclerosis.
- Men experienced more frequent dysphoria, focal neurological deficits, and pulse deficits.
- Women had higher rates of dissection-related pneumonia, pulmonary atelectasis, aortic intramural hematoma, ischemic electrocardiographic changes, and in-hospital complications including myocardial ischemia, hypoxemia, and cardiac tamponade.
- Women with type A dissection exhibited significantly higher in-hospital mortality compared to men.
Conclusions:
- The clinical presentation and outcomes of acute aortic dissection (AAD) differ significantly between sexes.
- Women with AAD face a higher risk of in-hospital complications and mortality, necessitating further research into sex-specific risk factors and therapeutic strategies.
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