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Updated: Mar 24, 2026

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
Published on: June 4, 2015
Effects of shear rate, confinement, and particle parameters on margination in blood flow
Marmar Mehrabadi1, David N Ku1, Cyrus K Aidun1
1George W. Woodruff School of Mechanical Engineering and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Abstract:
The effects of flow and particle properties on margination of particles in red blood cell (RBC) suspensions is investigated using direct numerical simulation (DNS) of cellar blood flow. We focus on margination of particles in the flow of moderately dense suspensions of RBCs. We hypothesize that margination rate in nondilute suspensions is mainly driven by the RBC-enhanced diffusion of marginating particles in the RBC-filled region. We derive a scaling law for margination length in a straight channel. Margination length increases cubically with channel height and is independent of shear rate. We verify this scaling law for margination length by DNS of flowing RBCs and marginating particles. We also show that rigidity and size both lead to particle margination with rigidity having a more significant effect compared to size within the range of parameters in this study.
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