Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver-associated large granular lymphocytes: morphological and functional aspects.

K Kaneda1

  • 1Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Japan.

Archives of Histology and Cytology
|December 1, 1989
PubMed
Summary

Large granular lymphocytes (LGLs) in the liver exhibit rapid natural killer (NK) cytotoxicity against tumor cells. Their unique granules and vesicles are key to this rapid immune defense within the liver microenvironment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction notice to "Post-tetanic count and single twitch height at the onset of reflex movement after administration of vecuronium under different types of anaesthesia" [Br J Anaesth 1994; 72: 688-690].

British journal of anaesthesia·2018
Same author

Retraction notice to "Infusion of amino acid enriched solution hastens recovery from neuromuscular block caused by vecuronium" [Br J Anaesth 2001; 86: 814-821].

British journal of anaesthesia·2018
Same author

Retraction notice to "Monitoring of neuromuscular block after administration of vecuronium in patients with diabetes mellitus" [Br J Anaesth 2003; 90: 480-486].

British journal of anaesthesia·2018
Same author

Quasi-solid electrolyte: a thixotropic gel of imogolite and an ionic liquid.

Chemical communications (Cambridge, England)·2016
Same author

Short fusion strategy for thoracolumbar and lumbar adolescent idiopathic scoliosis using anterior dual-rod instrumentation.

The bone & joint journal·2016
Same author

The long-term use of soap does not affect the pH-maintenance mechanism of human skin.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2014

Area of Science:

  • Immunology
  • Cell Biology
  • Hepatology

Background:

  • Large granular lymphocytes (LGLs) are lymphocytes with distinct recirculation patterns, found in nonlymphoid organs like the liver and lungs.
  • Liver-associated LGLs, also known as pit cells, adhere to sinusoidal endothelium and possess natural killer (NK) cytotoxicity.
  • These cells have unique organelles, dense granules and rod-cored vesicles, crucial for their cytotoxic function.

Purpose of the Study:

  • To elucidate the role and mechanisms of liver-associated LGLs in hepatic immune surveillance.
  • To describe the morphology and function of LGLs, focusing on their cytotoxic organelles.
  • To understand the regulatory microenvironment of liver sinusoids influencing LGL activity.

Main Methods:

  • Morphological studies of LGLs, particularly pit cells.

Related Experiment Videos

  • Analysis of LGL cytotoxic mechanisms involving dense granules and rod-cored vesicles.
  • Investigation of the liver sinusoidal microenvironment's role in regulating LGL function.

    • Main Results:

    • LGLs demonstrate rapid NK cytotoxicity against metastatic tumor cells without requiring lymphoid tissue processing.
    • Dense granules (lysosomes) contain pore-forming proteins, and rod-cored vesicles are secretory vesicles that increase with augmented NK function.
    • The liver microenvironment, including Kupffer cells and endothelial cells, regulates liver-associated LGL function.

    Conclusions:

    • Liver-associated LGLs are integral to the liver's rapid defense system against tumor cells.
    • The unique organelles of LGLs are essential for their cytotoxic activity.
    • LGLs and Kupffer cells play intrinsic roles in liver defense under physiological and pathological conditions.