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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Related Experiment Video

Updated: Mar 24, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Breast Molecular Profiling and Radiotherapy Considerations.

Omar Mahmoud1, Bruce G Haffty2

  • 1Department of Radiation Oncology, Robert Wood Johnson Medical School, New Jersey Medical School and Rutgers Cancer Institute of New Jersey, NJ, New Brunswick, USA.

Advances in Experimental Medicine and Biology
|March 19, 2016
PubMed
Summary
This summary is machine-generated.

Molecular profiling reveals breast cancer heterogeneity, improving treatment predictions. Further research is needed to guide locoregional management using genomic data for better patient outcomes.

Keywords:
Breast cancerMolecular signatureRadiotherapySubtyping

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Area of Science:

  • Oncology
  • Genomics
  • Cancer Biology

Background:

  • Breast cancer management has evolved significantly over the past decade.
  • Significant heterogeneity exists in breast cancer histology, treatment response, and patient outcomes.
  • Molecular profiling offers a more accurate method for predicting treatment outcomes than traditional clinicopathologic features.

Purpose of the Study:

  • To review the molecular classification of breast cancer.
  • To explore the association between molecular subtypes and locoregional outcomes.
  • To discuss radiobiological properties and radiotherapy considerations for different breast cancer subtypes.

Main Methods:

  • Review of available data on molecular classification of breast cancer.
  • Analysis of associations between molecular subtypes and locoregional outcomes.
  • Evaluation of radiobiological properties and radiotherapy considerations.

Main Results:

  • Genomic profiling has unveiled the heterogeneity of breast cancer, identifying distinct biologic subtypes.
  • Molecular profiling accurately predicts treatment benefits and overall survival.
  • The role of genotyping in guiding locoregional management requires further investigation.

Conclusions:

  • Molecular classification is crucial for understanding breast cancer heterogeneity and predicting patient outcomes.
  • Genomic data integration into clinical management enhances systemic therapy decisions.
  • Further characterization is necessary to leverage molecular profiling for locoregional treatment strategies, including radiotherapy.