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Implication of protein tyrosine phosphatase SHP-1 in cancer-related signaling pathways

Yadhu Sharma1, Altaf Ahmad2, Samina Bashir1

  • 1Department of Biochemistry, Faculty of Science, Jamia Hamdard, New Delhi-110062, India.

Future Oncology (London, England)
|March 19, 2016
PubMed

Insights

SHP-1 (SH2 domain-containing protein tyrosine phosphatase) alterations are linked to cancer. This review analyzes SHP-1

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • SHP-1 (SH2 domain-containing protein tyrosine phosphatase) expression is altered in cancer via methylation or mutations.
  • SHP-1 negatively regulates cell cycle and inflammatory pathways crucial for oncogenesis.
  • SHP-1 plays a significant role in immune cell signaling.

Purpose of the Study:

  • To critically analyze the role of SHP-1 in cancer progression.
  • To investigate SHP-1's regulation of cell cycle and JAK/STAT pathways.
  • To explore SHP-1's potential as a prognostic marker and therapeutic target in cancer.

Main Methods:

  • Literature review and critical analysis.
  • Focus on SHP-1's involvement in cell cycle regulation.
  • Emphasis on SHP-1's role in the JAK/STAT signaling pathway.

Main Results:

  • Altered SHP-1 expression is associated with cancer development.
  • SHP-1 influences key cell cycle components.
  • SHP-1 impacts the JAK/STAT pathway, relevant to inflammation and cancer.

Conclusions:

  • SHP-1 is a critical regulator of pathways involved in cancer progression.
  • SHP-1 presents a promising target for cancer therapy.
  • Further research can establish SHP-1 as a prognostic marker for cancer.
Keywords:
SHP-1STAT3cancercyclin dependent kinasesmotheaten micep27kip1viable motheaten mice

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