Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transgenic mice.

C Babinet1, D Morello, J P Renard

  • 1Institut Pasteur, Unité de génétique des mammifères, Paris, France.

Genome
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Transgenic mice allow stable integration of foreign DNA, enabling precise study of gene function and expression patterns in vivo. This powerful technique aids in understanding gene roles and developing new research avenues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetism of A-copper(II) bimetallic chain compounds (A = iron, cobalt, nickel): one- and three-dimensional behaviors.

Inorganic chemistry·2013
Same author

A euglycaemic/non-diabetic perinatal environment does not alleviate early beta cell maldevelopment and type 2 diabetes risk in the GK/Par rat model.

Diabetologia·2012
Same author

Quality and safety of bovine clones and their products.

Animal : an international journal of animal bioscience·2012
Same author

[Adherence to glaucoma therapy].

Journal francais d'ophtalmologie·2010
Same author

[Analysis of a new visual field index, the VFI, in Ocular Hypertension and Glaucoma].

Journal francais d'ophtalmologie·2009
Same author

Retrotransposon expression as a defining event of genome reprogramming in fertilized and cloned bovine embryos.

Reproduction (Cambridge, England)·2009
Same journal

Abiotic stress-responsive tRNA-derived fragments in pitanga (<i>Eugenia uniflora</i> L.): regulatory roles in drought and salinity adaptation.

Genome·2026
Same journal

Diacylglycerol kinase promotes forgetting of aversive olfactory memory in Drosophila.

Genome·2026
Same journal

From Lab Bench to Public Voice: How to Incorporate Science Communication into Your Research Program.

Genome·2026
Same journal

<i>delimtools</i>: an R package for species delimitation.

Genome·2026
Same journal

The mitochondrial genome of pequi tree (Caryocar brasiliense Cambess.): Genome structure, gene transfers, and evolutionary insights within Malpighiales.

Genome·2026
Same journal

The genome sequence of the açaí berry (<i>Euterpe oleracea</i> Mart.) and RNA-Seq analysis of the fruit ripening.

Genome·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Stable integration of exogenous genetic material into the mouse genome is a key technique in biological research.
  • Transgenes are typically expressed correctly in terms of spatial and temporal patterns.
  • This approach allows for the definition of cis-acting DNA sequences that regulate gene expression specificity.

Purpose of the Study:

  • To explore the utility of transgenic mice for studying gene function and regulation.
  • To investigate the physiological roles of specific gene products by targeted expression.
  • To leverage transgene insertion for identifying and cloning endogenous genes affected by insertional mutagenesis.

Main Methods:

  • Generation of transgenic mouse lines with various gene constructs.

Related Experiment Videos

  • Analysis of spatial and temporal transgene expression patterns.
  • Utilizing transgenes as tags for cloning disrupted endogenous genes.
  • Application of homologous recombination in embryonic stem cells for germline modification.

    • Main Results:

    • Transgenic mice facilitate the study of cis-acting DNA elements controlling gene expression.
    • Targeted gene product delivery provides insights into physiological roles, such as oncogene function in cancer.
    • Insertional mutagenesis by foreign DNA allows for the identification of novel endogenous genes.
    • Homologous recombination in stem cells offers a future method for detailed mammalian genome analysis.

    Conclusions:

    • Transgenic mouse technology is a potent tool for dissecting gene function and regulation in a developmental context.
    • The ability to target gene expression and use transgenes as tags significantly advances biological research.
    • Future applications, including homologous recombination, promise deeper understanding of mammalian genome function.