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[A clinical study on the relationship of autonomic nervous function and arteriosclerosis in patients with essential

G Zhao1, S H Li, X Tan

  • 1Department of Cardiology, Chang'an Branch of First People's Hospital of Liangshan, Xichang 615000, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|March 19, 2016
PubMed

Insights

Autonomic nervous system dysfunction, indicated by heart rate variability and blood pressure variability, is linked to arteriosclerosis in essential hypertension patients. This suggests sympathetic activation and vascular damage are interconnected.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Autonomic Nervous System Studies

Background:

  • Essential hypertension is a major risk factor for cardiovascular diseases, including arteriosclerosis.
  • Autonomic nervous system (ANS) dysfunction plays a role in the pathophysiology of hypertension and its complications.

Purpose of the Study:

  • To investigate the relationship between autonomic nervous function and arteriosclerosis in patients with essential hypertension.
  • To determine if heart rate variability (HRV) and blood pressure variability (BPV) are associated with arteriosclerosis markers in hypertensive individuals.

Main Methods:

  • Carotid-femoral pulse wave velocity (PWV) was used to assess arteriosclerosis in 269 essential hypertension patients.
  • Simultaneous 24-hour ambulatory blood pressure monitoring and dynamic electrocardiogram were performed to measure HRV and BPV.
  • Statistical analyses included Pearson correlation and multivariate logistic regression.

Main Results:

  • Patients with higher PWV (indicating arteriosclerosis) showed significantly altered HRV and BPV indices compared to those with normal PWV.
  • PWV was positively correlated with several BPV indices (e.g., 24-hour'sSSD, 24-hour'sPP) and specific HRV markers (LF, LF/HF, night/day heart rate ratio).

Conclusions:

  • Heart rate variability and blood pressure variability are positively correlated with arteriosclerosis in essential hypertension.
  • Findings suggest a close relationship between sympathetic nervous system activation and vascular injury in this patient group.
Abstract

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