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[Association between neutrophil-lymphocyte ratio and isolated coronary artery ectasia: a meta-analysis]
1First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.
Objective:
To evaluate the association between neutrophil-lymphocyte ratio (NLR) and isolated coronary artery ectasia by meta-analysis.
Methods:
Case-control studies focusing the association between NLR and isolated coronary artery ectasia published before July 2015 were identified from PubMed, CBM, CNKI, WanFang, and VIP databases and references of related studies were also searched manually. After document screening, data extraction and quality evaluation, meta-analysis was performed using RevMan 5.3 software.
Results:
Five case-control studies including 817 patients were identified. The result of meta-analysis showed the NLR level in the isolated coronary artery ectasia group was significantly higher than that of the control group (MD=0.89, 95%CI 0.07-1.00, P<0.01), and the loss of safety coefficient was 335 showing that the result of meta-analysis was reliable.
Conclusions:
Results from the present meta-analysis show that elevated NLR level may be associated with the presence of isolated coronary artery ectasia. However, further studies are warranted to establish the causal association between NLR level and presence of isolated coronary artery ectasia.
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