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The nutrient sensor OGT in PVN neurons regulates feeding

Olof Lagerlöf1, Julia E Slocomb2, Ingie Hong3

  • 1Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|March 19, 2016
PubMed
Summary

Scientists found that removing O-GlcNAc transferase (OGT) from specific brain cells in adult mice led to obesity due to overeating. This suggests O-GlcNAcylation in the hypothalamus is key for controlling feeding behavior and satiety.

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