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Related Experiment Videos

Renin in the bovine eye.

J Deinum1, F H Derkx, A H Danser

  • 1Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|December 1, 1989
PubMed
Summary

Researchers identified renin and prorenin in bovine eyes, with highest concentrations in the uveal tract. Vitreous fluid primarily contains prorenin, suggesting potential intraocular synthesis of these enzymes.

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Biochemistry

Background:

  • High prorenin levels have been observed in human ocular fluids.
  • The presence and distribution of renin-angiotensin system components within the eye warrant further investigation.

Purpose of the Study:

  • To identify and quantify renin and prorenin concentrations in the bovine eye.
  • To determine the distribution of these enzymes within different ocular tissues and fluids.

Main Methods:

  • Enzyme activity assays were performed on bovine ocular tissues and plasma.
  • Concentrations of total renin (renin plus prorenin) and prorenin were measured.

Main Results:

  • Renin and prorenin were detected in the bovine eye at levels unexplainable by plasma contamination.

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  • Total renin concentrations were highest in the posterior uveal tract (15.4 ng Ang I/g per h), followed by the anterior uveal tract (10.1), plasma (6.3), vitreous fluid (5.7), and retina (5.1).
  • Vitreous fluid predominantly contained prorenin (99%), while the retina (78%), anterior uveal tract (47%), and posterior uveal tract (32%) had lower prorenin proportions.

    • Conclusions:

    • The bovine eye contains significant levels of renin and prorenin, with distinct tissue distribution.
    • The high prorenin content in vitreous fluid suggests potential local synthesis within the eye, independent of plasma renin.
    • These findings support the hypothesis of intraocular renin-angiotensin system activity.