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Inhibitors of rat renin and their use in experimental hypertension
E C Beattie1, J J Morton, B J Leckie
1MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
Abstract:
Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) of human substrate peptides are potent in vitro inhibitors of rat renin with IC50 values as low as 0.8 nmol/l. When given to renal hypertensive rats they lower blood pressure and suppress both plasma renin and angiotensin II. There was a divergence between the rapid rebound of renin and blood pressure which remained suppressed.