Related Experiment Video

Updated: Mar 24, 2026

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
10:39

Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module

Published on: June 18, 2015

13.9K

Tamoxifen Action in ER-Negative Breast Cancer

Subrata Manna1, Marina K Holz2

  • 1Department of Biology, Yeshiva University, New York, NY, USA.

Signal Transduction Insights
|March 19, 2016
PubMed

Insights

Tamoxifen shows effectiveness in some estrogen receptor-negative breast cancers, independent of ER signaling. Further research into molecular markers could improve treatments for ER-negative and triple-negative breast cancers.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Breast cancer heterogeneity impacts treatment efficacy.
  • Tamoxifen, a selective estrogen receptor (ER) modulator, is standard for ER-positive breast cancer.
  • A subset of ER-negative breast cancers also respond to tamoxifen.

Purpose of the Study:

  • To review tamoxifen's action in ER-negative breast cancer.
  • To explore molecular mechanisms beyond ER signaling in tamoxifen sensitivity.
  • To guide future therapeutic strategies for ER-negative and triple-negative breast cancers.

Main Methods:

  • Literature review of studies on tamoxifen sensitivity in breast cancer.
  • Analysis of molecular markers and signaling pathways.
  • Examination of epigenetic factors and tumor microenvironment.

Main Results:

  • Tamoxifen sensitivity in ER-negative breast cancer is linked to ER-independent pathways.
  • Estrogen-related receptor alpha, ER subtype beta, tumor microenvironment, and epigenetics influence response.
  • ER-negative and triple-negative breast cancers present unique therapeutic challenges.

Conclusions:

  • Understanding ER-independent pathways is crucial for treating ER-negative breast cancers.
  • Targeting these pathways may offer new therapeutic avenues.
  • Further research is needed to develop effective strategies for aggressive breast cancer subtypes.
Keywords:
breast cancertamoxifen

More Related Videos

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen19:44

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

19.3K
An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation08:48

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

Published on: June 30, 2015

8.7K

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
5.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.4K