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Published on: October 26, 2020
The effects of endothelin on renovascular resistance and renin release
1Department of Pharmacology, University of Heidelberg, Federal Republic of Germany.
Abstract:
In the isolated perfused rat kidney, endothelin inhibits renin release and reduces the renal perfusate flow. The half-maximally effective concentrations were 30 and 50 pmol/l, respectively. Both effects are slow in onset and in washout. The calcium channel antagonist nimodipine (2 mumol/l) completely blocks the vasoconstrictor and renin secretion response of a median inhibitory concentration (IC50) of endothelin, indicating that entry of external calcium may play a role. Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance.
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