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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Combination therapy with daclatasvir and asunaprevir for dialysis patients infected with hepatitis C virus
Ken Sato1, Yuichi Yamazaki1, Tatsuya Ohyama1
1Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Takeshi Kobayashi, Norio Horiguchi, Satoru Kakizaki, Masanobu Yamada, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Abstract:
The standard antiviral therapy for dialysis patients infected with hepatitis C virus (HCV) is (pegylated) interferon monotherapy, but its efficacy is insufficient. Oral direct-acting antiviral agents (DAAs) have recently been developed for chronic hepatitis C patients. However, some DAAs have contraindications for chronic renal failure (CRF). Daclatasvir and asunaprevir are metabolized largely in the liver and are not contraindicated in CRF. Combination therapy with daclatasvir and asunaprevir was used for 4 dialysis patients infected with genotype 1b HCV. One patient had viral breakthrough, and the 3 others had sustained virological response 12. One patient was admitted for heart failure and percutaneous coronary intervention due to concomitant ischemic disease. Heart failure was unlikely to be caused by the combination therapy, as it was probably due to water overload. The patient continued to receive the combination therapy after the remission of the heart failure. The combination therapy was well tolerated in the other patients.
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