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Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory Markers in Essential Hypertension

Kamna Srivastava1, Rajiv Narang2, Jagriti Bhatia3

  • 1Dr. B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110007, India.

Plos One
|March 19, 2016
PubMed

Insights

Elevated Heat Shock Protein 70 (HSP70) gene and protein expression is significantly higher in patients with essential hypertension. This increased HSP70 expression correlates with inflammatory markers, suggesting a role in hypertension.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Immunology

Background:

  • Essential hypertension is a major risk factor for cardiovascular diseases.
  • Elevated inflammatory markers are linked to hypertension, but HSP70's role is unclear.
  • Previous studies show increased levels of TNF-alpha, IL-6, CRP, and p53 in hypertension.

Purpose of the Study:

  • To investigate Heat Shock Protein 70 (HSP70) expression at mRNA and protein levels in essential hypertension patients.
  • To explore the relationship between HSP70 and other inflammatory markers in essential hypertension.

Main Methods:

  • Real-time PCR used to measure HSP70 mRNA levels.
  • Indirect ELISA and Western Blot techniques employed for HSP70 protein quantification.
  • Study included 132 essential hypertension patients and 132 healthy controls.

Main Results:

  • HSP70 gene expression was significantly higher (approx. 6.45 fold) in hypertensive patients versus controls (P < 0.0001).
  • HSP70 protein expression in plasma was also significantly elevated in patients compared to controls (P < 0.0001).

Conclusions:

  • Increased HSP70 expression is positively correlated with inflammatory markers in essential hypertension.
  • This correlation may indicate an important role for HSP70 in the pathogenesis of essential hypertension.
Abstract

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