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Feedback, Lineages and Self-Organizing Morphogenesis.

Sameeran Kunche1,2, Huaming Yan2,3, Anne L Calof2,4,5

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Summary
This summary is machine-generated.

Feedback mechanisms controlling stem cell self-renewal drive tissue morphogenesis. This mathematical model reveals how opposing signals can trigger complex growth patterns and self-organization, independent of cell cycle speed.

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Area of Science:

  • Developmental Biology
  • Mathematical Modeling
  • Cell Biology

Background:

  • Feedback regulation is crucial for tissue size homeostasis.
  • Its role in tissue morphogenesis remains largely unexplored.

Purpose of the Study:

  • To investigate the role of feedback regulation in tissue morphogenesis using mathematical modeling.
  • To explore how specific feedback architectures influence cell behavior and tissue development.

Main Methods:

  • Utilized mathematical modeling to simulate feedback mechanisms.
  • Focused on diffusible signals acting on stem and progenitor cells.
  • Analyzed the impact of feedback on cell self-renewal, not cell cycle speed.

Main Results:

  • Identified a feedback architecture generating bistable/bi-modal growth.
  • Demonstrated ultrasensitivity to external growth cues.
  • Observed local growth-driven budding, self-sustaining elongation, and self-organization into lamellar fingers.
  • Showed that morphogenesis arises from stem/progenitor self-renewal control.

Conclusions:

  • Feedback regulation of stem/progenitor self-renewal is a key driver of tissue morphogenesis.
  • Antagonistic diffusible signals can induce complex spatial patterns and self-organization.
  • Morphogenesis in this model is not driven by Turing-type instabilities.