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Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts

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Published on: March 26, 2015

Acrokeratoelastoidosis.

Euphemia W Mu¹, Adnan Mir, Shane A Meehan

¹New York University School of Medicine.

Dermatology Online Journal

|March 19, 2016

Summary

This summary is machine-generated.

Acrokeratoelastoidosis, a rare skin condition, presents as palmoplantar keratoderma with characteristic changes in elastic fibers. This case highlights diagnostic challenges and limited treatment options for this condition.

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Area of Science:

Dermatology
Histopathology

Background:

Acrokeratoelastoidosis is a rare genetic disorder causing palmoplantar keratoderma.
It is characterized by hyperkeratosis and abnormal elastic fibers on the hands and feet.

Observation:

A 32-year-old man presented with multiple keratotic papules and plaques on his hands and feet.
Histopathology revealed compact orthokeratosis and fragmented elastic fibers.

Findings:

The findings are consistent with acrokeratoelastoidosis.
Differential diagnosis includes focal acral hyperkeratosis, distinguished by normal elastic fibers.

Implications:

Early diagnosis is crucial for managing acrokeratoelastoidosis.
Current treatments show minimal efficacy, necessitating further research into novel therapeutic strategies.