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Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Mar 24, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

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Squamous-cell carcinoma in situ.

Lisa R Rothman1, Adnan Mir, Shane A Meehan

  • 1New York University School of Medicine.

Dermatology Online Journal
|March 19, 2016
PubMed
Summary

A woman developed squamous-cell carcinoma in situ after prolonged ultraviolet C (UVC) radiation exposure. This case highlights UVC radiation as a potential risk factor for non-melanoma skin cancer (NMSC) as its use increases.

Area of Science:

  • Dermatology
  • Oncology
  • Radiation Biology

Background:

  • Atopic dermatitis and ichthyosis vulgaris are common chronic inflammatory skin conditions.
  • Ultraviolet C (UVC) radiation is increasingly used for antimicrobial purposes.
  • Non-melanoma skin cancer (NMSC) encompasses various skin malignancies, with squamous-cell carcinoma being a common type.

Observation:

  • A 30-year-old woman with pre-existing atopic dermatitis and ichthyosis vulgaris presented with a persistent erythematous, scaly plaque on her right hand.
  • The plaque developed three years after a laboratory accident involving prolonged accidental exposure to UVC radiation.
  • Initial diagnosis was eczematous dermatitis, but histopathological examination revealed squamous-cell carcinoma in situ.

Findings:

  • This case represents the first documented instance of NMSC developing in a skin area with documented acute UVC radiation exposure.

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  • The development of squamous-cell carcinoma in situ suggests a potential link between UVC radiation and skin cancer development.

    • Implications:

    • As UVC antimicrobial technology adoption grows, UVC radiation exposure may emerge as a significant risk factor for NMSC.
    • Further research is warranted to definitively establish causation and understand the long-term risks associated with UVC exposure.
    • Clinicians should consider UVC radiation exposure history in patients presenting with suspicious skin lesions, particularly those with pre-existing skin conditions.