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Updated: Mar 24, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
11.0K
Benign familial pemphigus (Hailey-Hailey disease)
Forrest White1, Marianna Shvartsbeyn, Shane A Meehan
1New York University School of Medicine.
Dermatology Online Journal
|March 19, 2016
Summary
Botulinum toxin type A offers a promising treatment for severe Hailey-Hailey disease, effectively resolving skin plaques when other therapies fail. This novel approach targets extensive cases, improving patient outcomes.
Area of Science:
- Dermatology
- Cutaneous Medicine
Background:
- Hailey-Hailey disease is a chronic, relapsing blistering skin disorder.
- Traditional treatments including antibiotics and glucocorticoids often prove ineffective for extensive disease.
Observation:
- A 56-year-old male patient presented with a 15-year history of refractory scaly red plaques on the trunk and axillae.
- Skin biopsy confirmed Hailey-Hailey disease.
Findings:
- Subcutaneous botulinum toxin type A injections were administered to the axillae and back.
- This treatment resulted in nearly complete resolution of plaques in the treated areas.
Implications:
- Botulinum toxin type A represents a potential new therapeutic option for extensive and treatment-refractory Hailey-Hailey disease.
- Further research may validate its role in managing this debilitating condition.
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