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Keratolysis exfoliativa.

Amelia K Hausauer¹, David E Cohen

¹New York University School of Medicine.

Dermatology Online Journal

|March 19, 2016

Summary

This summary is machine-generated.

Keratolysis exfoliativa (KE) is a skin condition causing peeling on hands and feet. Oral acitretin showed significant improvement in a patient unresponsive to topical treatments, suggesting a new therapeutic option for this condition.

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Area of Science:

Dermatology
Dermatopathology
Pharmacology

Background:

Keratolysis exfoliativa (KE) is a distinct palmoplantar eruption characterized by superficial collarettes of scale.
KE presents as air-filled bullae on an erythematous base, leading to lamellar peeling.
It is differentiated from other volar skin conditions like dyshidrosis and contact dermatitis.

Observation:

A 55-year-old woman presented with extensive keratolysis exfoliativa affecting her hands and feet.
The patient did not respond to conventional topical therapies.
A dose-response improvement was observed with oral acitretin treatment.

Findings:

Recent studies link KE to premature corneo-desmosomal disruption.
Acitretin is known to treat disorders of abnormal corneocyte desquamation, such as Netherton's disease.
This case report is the first to document the efficacy of systemic acitretin in treating keratolysis exfoliativa.

Implications:

Systemic acitretin may be a viable therapeutic option for recalcitrant keratolysis exfoliativa.
Understanding the role of corneo-desmosomal disruption in KE could lead to targeted therapies.
This finding expands treatment possibilities for patients with severe or treatment-resistant KE.