Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

6.9K
6.9K
Amyloid Fibrils03:03

Amyloid Fibrils

12.8K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.8K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

897
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
897
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
The Nucleolus02:55

The Nucleolus

10.6K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mouse model of Merkel cell carcinoma derived from the hair follicle.

The Journal of investigative dermatology·2026
Same author

Epithelioid Fibrous Histiocytoma With Giant Cells and VCL-Anaplastic Lymphoma Kinase Fusion: A Diagnostic Challenge.

The American Journal of dermatopathology·2026
Same author

LYP vs. advanced-stage CTCLs: Single-cell profiling reveals markers of self-limited vs. aggressive disease behavior.

Blood advances·2026
Same author

Persistent thrombotic events in a seronegative patient with antiphospholipid syndrome.

JAAD case reports·2026
Same author

Rupioid Id Reaction With Peripheral Eosinophilia.

Cutis·2026
Same author

Establishing dermatopathology encyclopedia DermpathNet with Artificial Intelligence-Based Workflow.

Scientific data·2026
Same journal

Pellagra associated with iron deficiency.

Dermatology online journal·2026
Same journal

Demodicosis: A frequently underrecognized cause of recalcitrant ear pruritus.

Dermatology online journal·2026
Same journal

Association of alopecia areata with COVID-19 vaccination: A vaccine adverse events reporting system analysis.

Dermatology online journal·2026
Same journal

Gender based price differences in 5% minoxidil foam: The impact of generic alternatives and bulk packaging.

Dermatology online journal·2026
Same journal

Retrospective analysis of filler complications reported in the manufacturer and user facility device experience database from 2015 to 2025.

Dermatology online journal·2026
Same journal

Characterizing barriers to care in patients with hidradenitis suppurativa.

Dermatology online journal·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

56.5K

Nodular amyloidosis.

Forrest White1, Marianna Shvartsbeyn, Shane A Meehan

  • 1New York University School of Medicine.

Dermatology Online Journal
|March 19, 2016
PubMed
Summary
This summary is machine-generated.

Nodular amyloidosis, a rare skin condition, presents as asymptomatic plaques. Diagnosis requires skin biopsy, and patients need monitoring for potential systemic disease progression.

More Related Videos

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.6K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.2K

Related Experiment Videos

Last Updated: Mar 24, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

56.5K
Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.6K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.2K

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Primary cutaneous amyloidosis encompasses several subtypes, with nodular amyloidosis being the rarest.
  • This condition involves amyloid deposition primarily in the skin.

Observation:

  • A case study of a 74-year-old woman with an 8-year history of asymptomatic, hyperpigmented pretibial plaques.
  • The lesions were characterized by their chronic and asymptomatic nature.

Findings:

  • Skin biopsy revealed amorphous eosinophilic material deposits throughout the dermis.
  • Congo-red staining demonstrated characteristic apple-green birefringence, confirming nodular amyloidosis.

Implications:

  • Nodular amyloidosis diagnosis necessitates evaluation for underlying systemic amyloidosis.
  • Long-term patient follow-up is crucial due to a small risk of systemic progression.