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Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish

Yuichiro Mishima1, Yukihide Tomari1

  • 1Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Molecular Cell
|March 19, 2016
PubMed
Summary

Maternal mRNA degradation in zebrafish is controlled by uncommon codons, promoting deadenylation. This process is influenced by 3' untranslated region length, revealing a conserved mRNA decay mechanism.

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