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A default method to specify skeletons for Bayesian model averaging continual reassessment method for phase I clinical

Haitao Pan1,2, Ying Yuan1

  • 1Department of Biostatistics, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, 77030, TX, U.S.A.

Statistics in Medicine
|March 19, 2016
PubMed
Summary

This study introduces a default method for selecting skeletons in Bayesian model averaging continual reassessment method (CRM) dose-finding trials. The approach enhances model selection accuracy for determining the maximum tolerated dose.

Keywords:
BMA-CRMBayesian adaptive designcontinual reassessment methodmaximum tolerated doseskeleton specification

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