Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

1.2K
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
1.2K
Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.8K
Long-term Potentiation01:35

Long-term Potentiation

59.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.4K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.3K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.3K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.4K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.4K
Long-Term Memory01:18

Long-Term Memory

817
Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
817

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phantom Quantification of Magnetoencephalography Source Imaging Distortion Caused by Deep Brain Stimulation.

Brain sciences·2026
Same author

Structure-function coupling of large-scale cortical networks across the lifespan is spectrally specific.

Communications biology·2026
Same author

Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth.

The Journal of physiology·2026
Same author

Adults with Down syndrome display altered entrainment of occipital cortical neurons.

Brain communications·2026
Same author

Understanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis.

Brain connectivity·2026
Same author

Hippocampal and cortical oscillatory dynamics support semantic processing and performance.

Communications biology·2026

Related Experiment Video

Updated: Mar 24, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K

Aging modulates the oscillatory dynamics underlying successful working memory encoding and maintenance.

Amy L Proskovec1,2, Elizabeth Heinrichs-Graham2,3, Tony W Wilson2,3,4

  • 1Department of Psychology, University of Nebraska - Omaha, Omaha, Nebraska.

Human Brain Mapping
|March 19, 2016
PubMed
Summary
This summary is machine-generated.

Older adults show distinct brain activity patterns during working memory tasks, particularly in language and prefrontal areas, suggesting compensatory mechanisms may support cognitive function with age.

Keywords:
Broca'sCRUNCHWernicke'salphacompensationmagnetoencephalographyoscillationprefrontal cortex

More Related Videos

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.8K
A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

14.2K

Related Experiment Videos

Last Updated: Mar 24, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

12.4K
An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
14:24

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

1.8K
A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
10:38

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

14.2K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Aging Research

Background:

  • Working memory is crucial for daily tasks but declines with age.
  • Neural mechanisms underlying age-related working memory decline are not fully understood.

Purpose of the Study:

  • To investigate age-related differences in neural dynamics during working memory.
  • To explore how age influences the relationship between brain activity and working memory performance.

Main Methods:

  • High-density magnetoencephalography (MEG) recorded brain activity in younger and older adults performing a high-load Sternberg task.
  • Time-frequency analysis and beamforming used to image oscillatory responses.
  • Hierarchical regression examined age as a moderator of neural activity and task accuracy.

Main Results:

  • Similar spatiotemporal dynamics in left fronto-temporal language areas across age groups.
  • Age-related differences observed in right-hemispheric homologues of Wernicke's and Broca's areas during encoding and maintenance.
  • Older adults showed stronger, earlier, and more widespread occipital alpha activity during maintenance.
  • Age moderated the relationship between prefrontal activity and accuracy, with decreasing prefrontal activity correlating with increased accuracy in younger adults.

Conclusions:

  • Neural oscillatory dynamics during working memory differ with age, particularly in right-hemispheric language homologues and prefrontal cortex.
  • Observed differences may represent compensatory mechanisms supporting working memory in older adults, aligning with the CRUNCH hypothesis.