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Updated: Mar 24, 2026
Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window
Published on: November 20, 2012
Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma
Robert C Rennert1, Achal S Achrol2, Michael Januszyk1,3
1Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Abstract:
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702-1707.
