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Metabolic rate and feeding behavior.

S Nicolaidis1, P Even

  • 1Neurobiologie des Régulations, CNRS URA 637, College de France, Paris.

Annals of the New York Academy of Sciences
|January 1, 1989
PubMed
Summary
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Hunger is linked to a drop in metabolic rate, according to the ischymetric hypothesis. Studies show that a decrease in resting metabolic rate (métabolisme de fond) precedes eating, and an increase follows it.

Area of Science:

  • Physiology
  • Metabolic Regulation
  • Neuroscience

Background:

  • The ischymetric hypothesis posits that hunger arises from a reduced metabolic rate.
  • Understanding the relationship between metabolic rate and feeding behavior is crucial for metabolic research.

Purpose of the Study:

  • To investigate the role of resting metabolic rate (métabolisme de fond, MF) in hunger and feeding patterns.
  • To examine the validity of the ischymetric hypothesis in rat models.

Main Methods:

  • Monitoring muscular contraction-free metabolic rate (MF) in rats using computerized open-circuit gas analysis.
  • Correlating MF with spontaneous and induced feeding behaviors.
  • Assessing the effects of pharmacological blockade of glucose and lipid utilization on feeding and MF.

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Main Results:

  • A decrease in MF preceded the onset of spontaneous meals, while an increase in MF followed meal termination.
  • Pharmacological inhibition of glucose and lipid utilization enhanced feeding by reducing MF.
  • Dexfenfluramine's anorexigenic effect was linked to MF enhancement via mobilization of endogenous fat reserves.

Conclusions:

  • Findings support the ischymetric hypothesis, linking hunger to decreased metabolic rate.
  • Metabolic rate modulation plays a significant role in feeding behavior and appetite control.
  • The ischymetric mechanism is a key factor in hunger, though influenced by hormonal, circadian, and environmental inputs.