Maternal obesity alters the apelinergic system at the feto-maternal interface
Sandy Hanssens1, Aurore Marx-Deseure1, Simon Lecoutre2
1CHRU of Lille, Jeanne de Flandre Hospital, Gynecology-Obstetrics, Lille, France; Univ. Lille, Unité Environnement Périnatal et Santé, EA 4489, Faculté de Médecine, Pôle recherche, IFR 114, 59045 Lille, France.
Abstract:
Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term and fetal apelinemia was sixfold higher than maternal level. Ex-vivo, the placenta releases apelin at E12.5 and E18.5. In HF pregnant mice at term, apelinemia as well as placental apelin and APJ mRNA levels were increased whereas placental release of apelin was drastically reduced compared to controls.
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