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Related Concept Videos

Endocytosis01:16

Endocytosis

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Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
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Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

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Overview
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Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

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Absorption of Nutrients01:19

Absorption of Nutrients

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Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
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Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

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Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
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Testing Epithelial Permeability in Fetal Tissue-Derived Enteroids
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Testing Epithelial Permeability in Fetal Tissue-Derived Enteroids

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Endocytosis in enterocytes.

Klaus-Peter Zimmer1, Jan de Laffolie2, Maria Vittoria Barone3

  • 1Department of General Pediatrics and Neonatology, Zentrum für Kinderheilkunde und Jugendmedizin UKGM, Standort Gießen/Justus-Liebig University, Feulgenstr. 12, 35392, Gießen, Germany. klaus-peter.zimmer@paediat.med.uni-giessen.de.

Wiener Medizinische Wochenschrift (1946)
|March 20, 2016
PubMed
Summary
This summary is machine-generated.

Endocytosis in enterocytes is crucial for nutrient absorption and immune responses. Understanding endocytosis defects offers new therapeutic avenues for inflammatory and inherited intestinal diseases.

Keywords:
Antigen presentationAutophagocytosisEndocytosisEnterocytesGliadin

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Area of Science:

  • Cell Biology
  • Gastroenterology
  • Immunology

Background:

  • Endocytosis is vital for enterocytes, facilitating nutrient absorption, barrier function, and immune cell interactions.
  • Enterocytes play a key role in antigen presentation and oral tolerance, processes involving endocytic pathways.
  • Dysfunctional endocytosis in enterocytes is implicated in inflammatory bowel diseases and inherited disorders.

Purpose of the Study:

  • To explore the role of endocytosis in enterocyte function and disease pathogenesis.
  • To investigate the involvement of endosomes in antigen processing and oral tolerance.
  • To highlight the potential of translational research for endocytosis-related enterocyte diseases.

Main Methods:

  • Review of cell and molecular biological studies on endocytosis in enterocytes.
  • Analysis of the role of endocytic pathways in inflammatory and inherited intestinal diseases.
  • Examination of translational research opportunities.

Main Results:

  • Endocytosis regulates nutrient/drug absorption, barrier permeability, and immune cell crosstalk in enterocytes.
  • Late endosomes are implicated in oral tolerance initiation and antigen processing in celiac and inflammatory bowel diseases.
  • Defects in endocytosis, autophagy, or recycling pathways are linked to inherited diseases like microvillus inclusion disease.

Conclusions:

  • Endocytosis is a fundamental process in enterocytes with significant implications for health and disease.
  • Targeting endocytic pathways presents novel therapeutic strategies for enterocyte-related disorders.
  • Advances in understanding endocytosis pave the way for improved patient treatments.