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Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein
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α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities

Camilla Lööv1, Clemens R Scherzer2, Bradley T Hyman3

  • 1Departments of Neurology and Radiology, Massachusetts General Hospital and Center for NeuroDiscovery, Harvard Medical School, Boston, MA, USA.

Cellular and Molecular Neurobiology
|March 20, 2016
PubMed
Summary

Toxic oligomers of alpha-synuclein, not fibrillar forms, drive Parkinson's disease (PD) pathology. Extracellular vesicles (EVs) may spread these harmful oligomers, offering potential diagnostic biomarkers in patient plasma.

Keywords:
ExosomesExtracellular vesiclesα-Synuclein

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